Pakistan Journal of Intensive Care Medicine 2023-04-11T04:56:17-04:00 Asim Rana Open Journal Systems <p>Articles for Pakistan Journal of Intensive Care Medicine (eISSN: 2789-2905; pISSN: 2789-2891) must be original reports of research not simultaneously submitted to or previously published in any other scientific or technical journal and must make a significant contribution to the advancement of knowledge or toward a better understanding of existing scientific concepts. The study reported should be applicable to a sizable geographic area or an area of ecological or economic significance and of potential interest to a significant number of scientists. Each calendar year will have one volume. PJICM publishes articles as soon as the final copy-edited version is approved by the authors rather than waiting for a collection of articles for a specific issue. Also, each article is published in its respective category (editorial, review, original or commentary). As a result, the page numbers in the ‘Table of Contents’ displayed for each issue will reflect this rather than numerical order. The journal aims to provide a platform of publications under the banner of <a href=""><em>Med</em>EYE Publishers</a> following eminent standards to the researchers, scholars, scientists and professionals of Biological and Medical Sciences. Inclusion of multiple academic disciplines helps in pooling the knowledge from two or more fields of study to handle better suited problems by finding solutions established on new understandings. The authors can submit manuscripts online through OJS. Authors can submit their manuscripts to editorial office along with any query through email at, <a href=""></a></p> ROLE OF STEM CELLS IN CARDIOVASCULAR DISEASES: A LITERATURE REVIEW 2023-04-08T19:57:19-04:00 MRO SIDDIQI T SARWAR R PERVAIZ AHA AWAD AM ABDELBAKY WG ELMASRY <p><em>Stem cells are of great significance, and their development has allowed healthcare workers to develop new treatment methods with more efficacy. Stem cells possess the ability to divide into all three germ layers but there are many ethical problems related to the use of these cells. Therefore, induced pluripotent stem cells (iPSCs) were developed from the somatic cells, especially fibroblasts to overcome these issues. These cells also have the ability to divide into all three germ layers without any ethical problem. This allows them to advance in the field of stem cells. With their development scientists are now working on developing regenerative medicines. Heart problems are one of the leading causes of death around the globe and these iPSCs can help overcomes these problems with more efficacy and the least side effects.</em></p> 2023-04-11T00:00:00-04:00 Copyright (c) 2023 MRO SIDDIQI, T SARWAR, R PERVAIZ, AHA AWAD, AM ABDELBAKY , WG ELMASRY ASSESSMENT OF D. DIMER VALUE IN COVID-19 INFECTED PATIENTS 2023-04-11T04:56:17-04:00 R PERVAIZ B ARIF K TEHREEM N GULL A MUNAWAR S RAZA M SUFIYAN <p><em>A global catastrophe caused by the COVID-19 epidemic has had negative effects on both health and the economy. The coagulation system may be involved in the pathophysiology of COVID-19 since D-Dimer, a measure of hypercoagulability, is higher in COVID-19 individuals with severe illness. In order to determine whether there is a relationship between D-Dimer levels and disease severity, this study measured the levels of D-Dimer in COVID-19 patients with severe and non-severe disease. The average age of the 72 confirmed COVID-19 patients in the research was 52.85 10.65. Based on the severity, the individuals were split into two groups, and the levels of D-Dimer were measured in each group. In contrast to individuals with less severe symptoms, those with severe COVID-19 symptoms had considerably higher levels of D-Dimer, according to the study. Cough, fever, breathing difficulties, and gastrointestinal symptoms were also discovered in the study to be statistically significant in patients with severe symptoms. The most prevalent co-morbid conditions among the individuals were hypertension and diabetes. These results emphasise the significance of identifying patients at risk for poor outcomes, tracking their D-Dimer levels and suggesting that D-Dimer levels may be a helpful prognostic marker in COVID-19 patients.</em></p> 2023-04-11T00:00:00-04:00 Copyright (c) 2023 R PERVAIZ, B ARIF, K TEHREEM, N GULL, A MUNAWAR, S RAZA, M SUFIYAN