https://pjicm.com/ojs/index.php/home <p>Articles for Pakistan Journal of Intensive Care Medicine (eISSN: 2789-2905; pISSN: 2789-2891) must be original reports of research not simultaneously submitted to or previously published in any other scientific or technical journal and must make a significant contribution to the advancement of knowledge or toward a better understanding of existing scientific concepts. The study reported should be applicable to a sizable geographic area or an area of ecological or economic significance and of potential interest to a significant number of scientists. Each calendar year will have one volume. PJICM publishes articles as soon as the final copy-edited version is approved by the authors rather than waiting for a collection of articles for a specific issue. Also, each article is published in its respective category (editorial, review, original or commentary). As a result, the page numbers in the ‘Table of Contents’ displayed for each issue will reflect this rather than numerical order. The journal aims to provide a platform of publications under the banner of <a href="http://medeyepublishers.com/ojs/index.php/home/loj"><em>Med</em>EYE Publishers</a> following eminent standards to the researchers, scholars, scientists and professionals of Biological and Medical Sciences. Inclusion of multiple academic disciplines helps in pooling the knowledge from two or more fields of study to handle better suited problems by finding solutions established on new understandings. The authors can submit manuscripts online through OJS. Authors can submit their manuscripts to editorial office along with any query through email at, <a href="mailto:editorbcsrj@gmail.com">editorpjicm@gmail.com.</a></p> Medeye Publishers en-US Pakistan Journal of Intensive Care Medicine 2789-2891 https://pjicm.com/ojs/index.php/home/article/view/32 <p><strong><em>Introduction:</em></strong><em> Brain herniation, or brain code, is a critical condition caused by elevated intracranial pressure, leading to abnormal brain tissue protrusion. Chronic herniations may be linked to developmental defects and remain asymptomatic, while acute herniations are life-threatening, especially after neurosurgery. <strong>Case Presentation:</strong> A 25-year-old female with Glioblastoma multiforme presented with facial weakness. Initially suspected as Bell’s Palsy, her condition rapidly worsened, leading to coma and signs of raised intracranial pressure. A CT scan revealed a brain tumor with associated edema, hemorrhage, and multiple herniations. Emergency craniectomy and subsequent medical management showed initial improvement, but she later developed ischemia and infarction, resulting in her death. <strong>Discussion:</strong> Timely diagnosis and intervention are crucial in managing brain herniation. Clinical signs and cranial nerve assessments are vital for diagnosis. Management focuses on reducing intracranial pressure through medical and surgical means. Early intervention is key to better outcomes, though the prognosis can be poor due to underlying conditions like Glioblastoma multiforme. <strong>Conclusion:</strong> Effective management of brain herniation requires timely surgical and medical intervention. This case illustrates the rapid progression and complexity of brain herniation, emphasizing the importance of early and comprehensive treatment.</em></p> R PERVAIZ T HAFEEZ N RAZA A RAZA S AQEEL MJ SHAHID M AHMED SMZU ABEDIN A ASHRAF A RUBEET Copyright (c) 2024 R PERVAIZ, T HAFEEZ, N RAZA, A RAZA, S AQEEL, MJ SHAHID, M AHMED, SMZU ABEDIN, A ASHRAF, A RUBEET https://creativecommons.org/licenses/by-nc/4.0 2024-07-05 2024-07-05 4 02 32 32 10.54112/pjicm.v4i02.32 https://pjicm.com/ojs/index.php/home/article/view/33 <p>Pneumonia in invasively ventilated patients is a significant concern in the intensive care unit (ICU), often associated with increased morbidity, prolonged hospital stays, and high mortality rates. The emergence of multidrug-resistant (MDR) pathogens further complicates management. Inhaled antibiotics (IABs) have gained attention as an adjunctive or alternative treatment modality to systemic antibiotics, offering direct drug delivery to the lungs with potentially enhanced efficacy and reduced systemic toxicity. This review explores the role of inhaled antibiotics in treating pneumonia in invasively ventilated patients, focusing on pharmacological considerations, clinical efficacy, safety profiles, and limitations. Relevant evidence is derived from databases such as PubMed, Scopus, Web of Science, and Google Scholar, incorporating the latest studies and clinical trials to provide a comprehensive understanding.</p> BA ABDELRAHMAN MA RANA AHA AWAD AM ABDELBAKY WG ELMASRY MH SIDDIQUI M AHMAD Copyright (c) 2024 BA ABDELRAHMAN , MA RANA , AHA AWAD , AM ABDELBAKY , WG ELMASRY , MH SIDDIQUI , M AHMAD https://creativecommons.org/licenses/by-nc/4.0 2024-11-30 2024-11-30 4 02 33 33 10.54112/pjicm.v4i02.33