FREQUENCY OF PULMONARY HYPERTENSION IN HEMODIALYSIS PATIENTS PRESENTING AT TERTIARY CARE HOSPITAL
DOI:
https://doi.org/10.54112/pjicm.v5i02.102Keywords:
Pulmonary Hypertension, Hemodialysis, Chronic Kidney Disease, Echocardiography, Prevalence, Tertiary CareAbstract
Background: Pulmonary hypertension (PH) is a common and serious cardiovascular complication among patients undergoing hemodialysis. It contributes significantly to increased morbidity and mortality in this population, often remaining underdiagnosed due to a nonspecific clinical presentation. Objective: To determine the frequency of pulmonary hypertension in hemodialysis patients presenting at a tertiary care hospital. Study Design: Cross-sectional descriptive study. Setting: Nephrology Department, Rehman Medical College, Peshawar, Pakistan. Duration of Study: 17-September-2024 to 17-March-2025. Methods: A total of 148 hemodialysis patients aged between 18 and 70 years were enrolled. Pulmonary hypertension was diagnosed using Doppler echocardiography, defined as a mean pulmonary arterial pressure (mPAP) >25 mmHg at rest. Clinical evaluation included assessment of angina (Visual Analogue Scale score >3) and shortness of breath. Data were analyzed using descriptive statistics, and results were expressed as frequencies, percentages, means, and standard deviations. Results: The mean age of the study population was 47.55 ± 16.11 years. Of the 148 patients, 85 (57.4%) were male and 63 (42.6%) were female. Pulmonary hypertension was detected in 76 (51.4%) patients, indicating a high prevalence of cardiovascular complications among individuals on long-term hemodialysis. Conclusion: The study found a high frequency (51.4%) of pulmonary hypertension among hemodialysis patients, emphasizing the need for routine cardiovascular monitoring in this high-risk group to improve clinical outcomes and reduce long-term complications.
References
Kalantar-Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V. Chronic kidney disease. Lancet. 2021;398(10302):786-802. https://doi.org/10.1016/s0140-6736(21)00519-5
Arasu R, Jegatheesan D, Sivakumaran Y. Overview of hemodialysis access and assessment. Can Fam Physician. 2022;68(8):577-82. https://doi.org/10.46747/cfp.6808577
Pecoits-Filho R, Okpechi IG, Donner JA, Harris DC, Aljubori HM, Bello AK, et al. Capturing and monitoring global differences in untreated and treated end-stage kidney disease, kidney replacement therapy modality, and outcomes. Kidney Int Suppl. 2020;10(1):e3-9. https://doi.org/10.1016/j.kisu.2019.11.001
Murad MH, Elamin MB, Sidawy AN, Malaga G, Rizvi AZ, Flynn DN, et al. Autogenous versus prosthetic vascular access for hemodialysis: a systematic review and meta-analysis. J Vasc Surg. 2008;48(5):34-47. https://doi.org/10.1016/j.jvs.2008.08.044
Dhingra RK, Young EW, Hulbert-Shearon TE, Leavey SF, Port FK. Type of vascular access and mortality in US hemodialysis patients. Kidney Int. 2001;60(4):1443-51.
Himmelfarb J, Vanholder R, Mehrotra R, Tonelli M. The current and future landscape of dialysis. Nat Rev Nephrol. 2020;16(10):573-85. https://doi.org/10.1046/j.1523-1755.2001.00947.x
Li H, Xie L, Yang J, Pang X. Symptom burden amongst patients suffering from end-stage renal disease and receiving dialysis: A literature review. Int J Nurs Sci. 2018;5(4):427-31. https://doi.org/10.1016/j.ijnss.2018.09.010
Htay H, Bello AK, Levin A, Lunney M, Osman MA, Ye F, et al. Hemodialysis use and practice patterns: an international survey study. Am J Kidney Dis. 2021;77(3):326-35. https://doi.org/10.1053/j.ajkd.2020.05.030
Sautenet B, Tong A, Williams G, Hemmelgarn BR, Manns B, Wheeler DC, et al. Scope and consistency of outcomes reported in randomized trials conducted in adults receiving hemodialysis: a systematic review. Am J Kidney Dis. 2018;72(1):62-74. https://doi.org/10.1053/j.ajkd.2017.11.010
Galie N, Palazzini M, Manes A. Pulmonary arterial hypertension: from the kingdom of the near-dead to multiple clinical trial meta-analyses. Eur Heart J. 2010;31(17):2080–2086. https://doi.org/10.1093/eurheartj/ehq152
Galie N, Humbert M, Vachiery JL. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the diagnosis and treatment of pulmonary hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Heart J. 2016;37(1):67–119. https://doi.org/10.1093/eurheartj/ehv317
Tamura Y, Kumamaru H, Satoh T. Effectiveness and outcome of pulmonary arterial hypertension-specific therapy in Japanese patients with pulmonary arterial hypertension. Circ J. 2017;82(1):275–282. https://doi.org/10.1253/circj.CJ-17-0139
Hoeper MM, Humbert M, Souza R, Idrees M, Kawut SM, Sliwa-Hahnle K, Jing ZC, et al. A global view of pulmonary hypertension. Lancet Respir Med. 2016;4(4):306-22. https://doi.org/10.1016/s2213-2600(15)00543-3
Montani D, Girerd B, Jaïs X, Laveneziana P, Lau EMT, Bouchachi A, et al. Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation. Eur Respir J. 2021 https://doi.org/10.1183/13993003.04229-2020
Lau EMT, Giannoulatou E, Celermajer DS, Humbert M. Epidemiology and treatment of pulmonary arterial hypertension. Nat Rev Cardiol. 2017;14(10):603-14. https://www.nature.com/articles/nrcardio.2017.84
Mukhtar KN, Mohkumuddin S, Mahmood N. Frequency of pulmonary hypertension in hemodialysis patients. PaK J M.ed Sc 2014;30(6):1319-22. https://doi.org/10.12669/pjms.306.5525
Khurram A, Danial K, Ahmed K, Ali Z. Prevalence of Pulmonary Hypertension in Patients Undergoing Regular Maintenance Hemodialysis due to End Stage Renal Disease. APMC 2016;10(3):121-124. https://doi.org/10.29054/apmc/2016.277
Gurusamy K, Ramasubramanian V, Shankar P, Velu KB, Senthilkumar PK, Anand M, et al. Burden of Pulmonary Hypertension in End-Stage Renal Disease Patients Receiving Maintenance Hemodialysis: Evaluation Factors and Treatment Strategies. Cureus. 2024;16(9):e69123. https://doi.org/10.7759/cureus.69123
Karmani JK, Yaqoob N, Niazi AWK, Nisar A, Malik MS, Ahmed AS. Prevalence and Impact of Pulmonary Hypertension in Hemodialysis Patients. Ann Pak Inst Med Sci. 2024;20(4):713–716. https://doi.org/10.48036/apims.v20i4.1268
Bolignano D, Rastelli S, Agarwal R, Fliser D, Massy Z, Ortiz A, et al. Pulmonary hypertension in CKD. Am J Kidney Dis. 2013;61(4):612-22. https://doi.org/10.1053/j.ajkd.2012.07.029
Nagaraju SP, Bhojaraja MV, Paramasivam G, Prabhu RA, Rangaswamy D, Rao IR, Shenoy SV. Risk Factors of Pulmonary Hypertension in Patients on Hemodialysis: A Single Center Study. Int J Nephrol Renovasc Dis. 2021;14:487-494. https://doi.org/10.2147/IJNRD.S346184
Islam MZ, Akter T, Rahman AKMM. Frequency of pulmonary hypertension in chronic kidney disease patients (stages 3, 4, 5) at a tertiary care hospital. Int J Res Med Sci 2024;12:3622-7.
Siddiqa M, Kimber AC, Shabbir J. Multivariable prognostic model for dialysis patients with end-stage renal disease: An observational cohort study of Pakistan by external validation. Saudi Med J. 2021;42(7):714-720. https://doi.org/10.15537/smj.2021.42.7.20210082
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