IN HOSPITAL OUTCOMES IN PATIENTS PRESENTING WITH ACUTE DECOMPENSATED HEART FAILURE WITH HYPONATREMIA

Authors

  • M PARVEZ Department of Cardiology, HMC, Hayatabad Medical Complex, Peshawar, Pakistan
  • M EJAZ Department of Cardiology, DHQ Hospital, Nowshera, Pakistan
  • S SADIQ Department of Cardiology, HMC, Hayatabad Medical Complex, Peshawar, Pakistan
  • T MUHAMMAD Department of Cardiology, HMC, Hayatabad Medical Complex, Peshawar, Pakistan

DOI:

https://doi.org/10.54112/pjicm.v5i01.68

Keywords:

Acute Decompensated Heart Failure (ADHF), Hyponatremia, Heart Failure

Abstract

Background: Acute decompensated heart failure (ADHF) is characterized by the rapid onset or worsening of symptoms and signs of heart failure, often necessitating urgent hospitalization. Its prevalence continues to rise globally, significantly contributing to increased morbidity and mortality. Objective: To determine the in-hospital outcomes among patients presenting with acute decompensated heart failure and concomitant hyponatremia.
Study Design: Descriptive case series. Settings: Department of Cardiology, MTI-Hayatabad Medical Complex, Peshawar. Duration of Study: From 14 June 2022 to 14 December 2022. Methods: Patients meeting the predefined inclusion criteria were prospectively enrolled after obtaining informed written consent from the patients or their caregivers. Clinical assessments and serum sodium levels were monitored during hospitalization, and relevant in-hospital outcomes, including mortality, length of hospital stay, and rehospitalization rates, were meticulously documented. Results: Out of the enrolled cohort, 113 (71.5%) patients had a previous history of hyponatremia. During hospitalization, 54 (34.2%) patients died, 42 (26%) required hospital stays longer than six days, and 32 (20.3%) were rehospitalized after initial discharge. Conclusion: The presence of hyponatremia in patients hospitalized for ADHF at MTI-HMC was strongly associated with adverse clinical outcomes, including high mortality, prolonged hospitalization, and rehospitalization. Therefore, routine monitoring and management of serum sodium levels are strongly recommended for patients admitted with acute heart failure.

References

Teerlink JR, Alburikan K, Metra M, Rodgers JE. Acute decompensated heart failure update. Curr Cardiol Rev. 2018;11(1):53-62.

Njoroge JN, Teerlink JR. Pathophysiology and therapeutic approaches to acute decompensated heart failure. Circ Res. 2021;128(10):1468-86.

Rodriguez M, Hernandez M, Cheungpasitporn W. Hyponatremia in heart failure: pathogenesis and management. Curr Cardiol Rev. 2019;15(4):252-61.

Verbrugge FH, Steels P, Grieten L, Nijst P, Tang WH, Mullens W, et al. Hyponatremia in acute decompensated heart failure: depletion versus dilution. J Am Coll Cardiol. 2018;65(5):480-92.

Ali K, Workicho A, Gudina EK. Hyponatremia in patients hospitalized with heart failure: a condition often overlooked in low-income settings. Int J Gen Med. 2016;9:267-73.

De Vecchis R, Di Maio M, Di Biase G, Ariano C. Effects of hyponatremia normalization on the short-term mortality and rehospitalizations in patients with recent acute decompensated heart failure: a retrospective study. J Clin Med. 2016;5(10):92.

Abebe TB, Gebreyohannes EA, Tefera YG, Bhagavathula AS, Erku DA, Belachew SA, et al. The prognosis of heart failure patients: does sodium level play a significant role? PLoS One. 2018;13(11):e0207242.

Alataş ÖD, Yılmaztepe MA, Bayram NA. Evaluation of factors affecting mortality in hospitalized patients with heart failure. Turk Kardiyol Dern Ars. 2021;49(1):30-39. doi:10.5543/tkda.2021.09896

Savarese G, Lund LH. Global Public Health Burden of Heart Failure. Card Fail Rev. 2020;6:e10. doi:10.15420/cfr.2019.26

Triposkiadis F, Xanthopoulos A, Butler J. Cardiovascular aging and heart failure: JACC Review Topic of the Week. J Am Coll Cardiol. 2019;74(6):804-813. doi:10.1016/j.jacc.2019.06.047

Tromp J, Ouwerkerk W, Cleland JGF, et al. Sex-related differences in heart failure with preserved ejection fraction. J Am Coll Cardiol. 2020;76(10):1239-1250. doi:10.1016/j.jacc.2020.07.021

Kapoor JR, Kapoor R, Ju C, et al. Precipitating clinical factors, heart failure characterization, and outcomes in patients hospitalized with heart failure with preserved ejection fraction. Am J Med. 2021;134(5):673-683.e2. doi:10.1016/j.amjmed.2020.11.004

Gul H, Jabbar A, Nadeem N, et al. Early cardiovascular aging in South Asians: a narrative review. J Clin Hypertens (Greenwich). 2022;24(8):927-933. doi:10.1111/jch.14545

Metawee A, Kassem A, Abdelgawad M, et al. Gender differences in heart failure outcomes among patients hospitalized for acute decompensation. ESC Heart Fail. 2022;9(1):522-531. doi:10.1002/ehf2.13714

Akinboboye O. Socioeconomic disparities and heart failure outcomes: a contemporary review. Curr Heart Fail Rep. 2023;20(1):1-7. doi:10.1007/s11897-022-00569-x

Yancy CW, Jessup M, Bozkurt B, et al. 2022 ACC/AHA/HFSA guideline for the management of heart failure. J Am Coll Cardiol. 2022;79(17):e263-e421. doi:10.1016/j.jacc.2021.12.012

Chioncel O, Lainscak M, Seferovic PM, et al. Epidemiology and one-year outcomes of patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: ESC-HF Long-Term Registry. Eur J Heart Fail. 2017;19(12):1574-1585. doi:10.1002/ejhf.859

Shin J, Yoon CH, Han S, et al. Impact of smoking cessation on heart failure outcomes. ESC Heart Fail. 2022;9(6):3860-3868. doi:10.1002/ehf2.14171

McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599-3726. doi:10.1093/eurheartj/ehab368

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Published

2025-04-30

How to Cite

PARVEZ , M., EJAZ , M., SADIQ , S., & MUHAMMAD , T. (2025). IN HOSPITAL OUTCOMES IN PATIENTS PRESENTING WITH ACUTE DECOMPENSATED HEART FAILURE WITH HYPONATREMIA. Pakistan Journal of Intensive Care Medicine, 5(01), 68. https://doi.org/10.54112/pjicm.v5i01.68

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Original Research Articles