ASSOCIATION OF NON-SECRETORY MULTIPLE MYELOMA AND HYPOTHYROIDISM: A RARE CASE REPORT

Abstract

One uncommon subtype of MM is non-secretory multiple myeloma (NSMM), and its main characteristic is the lack of observable monoclonal proteins. The coexistence of hypothyroidism and MM is very rare, and little is known about their interaction. Presentation of the case: A known case of hypothyroidism, presented with fever, shortness of breath, and fatigue. Lytic lesions on skull X-ray, lack of proteins on protein electrophoresis, and bone marrow biopsy confirmed the diagnosis. The patient was treated with cyclophosphamide and dexamethasone. Discussion: This case demonstrates how challenging it can be to identify NSMM, especially when typical MM symptoms are absent. Since the concurrence of MM and hypothyroidism is very uncommon, more research is required. Conclusion: This study highlights the need for a multidisciplinary approach for the diagnosis and treatment of rare MM variants due to their atypical presentations. Further study is required to elucidate the underlying mechanisms and therapeutic implications of this association.