ASSESSMENT OF THYROID HORMONE ABNORMALITIES IN PATIENTS OF DOWN SYNDROME

MH SIDDIQUI; W IQBAL; MA RANA; M SUFIYAN; FSM SALEEM; R PERVAIZ

doi:10.54112/pjicm.v2i1.14

Authors

MH SIDDIQUI Department of medicine and endocrinology, Akhtar Saeed medical and dental college Lahore, Pakistan
W IQBAL Vice Principal, Red Cresent Medical and Dental College, Lahore, Pakistan
MA RANA Department of Critical Care Medicine, Amna Inayat Medical College & Bahria International Hospital, Lahore, Pakistan
M SUFIYAN Department of Medicine and Critical Care, Bahria International Hospital, Lahore, Pakistan
FSM SALEEM Department of Medicine and Critical Care, Bahria International Hospital, Lahore, Pakistan
R PERVAIZ Department of Medicine and Critical Care, Bahria International Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.54112/pjicm.v2i1.14

Keywords:

Down syndrome, Thyroid dysfunction, Euthyroid, Hypothyroidism, Hyperthyroidism, Sick thyroid syndrome

Abstract

Down syndrome is the fourth most come syndrome caused by chromosomal abnormalities. This syndrome includes many abnormalities such as thyroid hormone dysfunction. The current study was designed to determine the prevalence of thyroid dysfunction in clinically diagnosed cases of Down syndrome patients that were confirmed on karyotyping later before including in the study. This Cross-sectional study was carried out at different Hospitals of Lahore to find out the prevalence of thyroid hormone dysfunction in 50 clinically diagnosed Down syndrome (DS) subjects from September 2019 to May 2021 by measuring thyroid function tests (T3, T4, TSH), and antithyroid antibodies (ATA). A total 50 Down syndrome cases were included in the study and majority of the patients were males 33(66.0%) while 17(34.0%) were females. Thyroid dysfunction was found in 27 (54%) of DS subjects, of whom 13 (26.0%) had hypothyroidism, 08 (16.0%) were having subclinical hypothyroidism, 01 (2.0%) had sick thyroid syndrome, 4 (8.0%) were hyperthyroid and 01 (2.0%) was subclinical hyperthyroid. ATA was positive in 07 (14.0%) patients of DS, of whom 02 (28%) were males and 05 were females (72%), 03 had hypothyroidism, 02 had hyperthyroidism, 02 had subclinical hypothyroidism. remaining 23 (46.0%) were having euthyroid status. This study showed that 54% of Down syndrome patients that were clinically diagnosed had thyroid hormone dysfunction. It can be concluded that thyroid hormone dysfunction is found in high prevalence in DS patients.

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