• MRO SIDDIQI Department of Cardiology, United Medical and Dental College. Karachi
  • T SARWAR Department of Medicine and Critical Care, Bahria Town International Hospital Lahore, Pakistan
  • R PERVAIZ Department of Medicine and Critical Care, Bahria Town International Hospital Lahore, Pakistan
  • AHA AWAD Department of Intensive Care Medicine, Rashid Hospital, Dubai, United Arab Emirates
  • AM ABDELBAKY Department of Intensive Care Medicine, Rashid Hospital, Dubai, United Arab Emirates
  • WG ELMASRY Department of Intensive Care Medicine, Rashid Hospital, Dubai, United Arab Emirates



Stem cells, iPSCs, ESCs, Cardiovascular disorders


Stem cells are of great significance, and their development has allowed healthcare workers to develop new treatment methods with more efficacy. Stem cells possess the ability to divide into all three germ layers but there are many ethical problems related to the use of these cells. Therefore, induced pluripotent stem cells (iPSCs) were developed from the somatic cells, especially fibroblasts to overcome these issues. These cells also have the ability to divide into all three germ layers without any ethical problem. This allows them to advance in the field of stem cells. With their development scientists are now working on developing regenerative medicines. Heart problems are one of the leading causes of death around the globe and these iPSCs can help overcomes these problems with more efficacy and the least side effects.


Cappelleri, J. C., Lundy, J. J., and Hays, R. D. (2014). Overview of classical test theory and item response theory for the quantitative assessment of items in developing patient-reported outcomes measures. Clinical therapeutics 36, 648-662.

Carvalho, T. d., and Giaretta, A. A. (2013). Bioacoustics reveals two new syntopic species of Adenomera Steindachner (Anura: Leptodactylidae: Leptodactylinae) in the Cerrado of central Brazil. Zootaxa 3731, 533-551.

Chow, C. K., Teo, K. K., Rangarajan, S., Islam, S., Gupta, R., Avezum, A., Bahonar, A., Chifamba, J., Dagenais, G., and Diaz, R. (2013). Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. Jama 310, 959-968.

Clifton‐Brown, J., Harfouche, A., Casler, M. D., Dylan Jones, H., Macalpine, W. J., Murphy‐Bokern, D., Smart, L. B., Adler, A., Ashman, C., and Awty‐Carroll, D. (2019). Breeding progress and preparedness for mass‐scale deployment of perennial lignocellulosic biomass crops switchgrass, miscanthus, willow and poplar. Gcb Bioenergy 11, 118-151.

Collin, J., and Lako, M. (2011). Concise review: Putting a finger on stem cell biology: Zinc finger nuclease‐driven targeted genetic editing in human pluripotent stem cells. Stem cells 29, 1021-1033.

Davis, R. L., Weintraub, H., and Lassar, A. B. (1987). Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51, 987-1000.

Evans, M. J., and Kaufman, M. H. (1981). Establishment in culture of pluripotential cells from mouse embryos. nature 292, 154-156.

Fernandes, A., Pacheco, M., Ciríaco, L., and Lopes, A. (2015). Review on the electrochemical processes for the treatment of sanitary landfill leachates: present and future. Applied Catalysis B: Environmental 176, 183-200.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., and Andrews, D. W. (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death & Differentiation 25, 486-541.

Garber, M., Yosef, N., Goren, A., Raychowdhury, R., Thielke, A., Guttman, M., Robinson, J., Minie, B., Chevrier, N., and Itzhaki, Z. (2012). A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Molecular cell 47, 810-822.

Grobarczyk, B., Franco, B., Hanon, K., and Malgrange, B. (2015). Generation of isogenic human iPS cell line precisely corrected by genome editing using the CRISPR/Cas9 system. Stem Cell Reviews and Reports 11, 774-787.

Gurdon, J. B., Elsdale, T. R., and Fischberg, M. (1958). Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei. Nature 182, 64-65.

Hanna, J., Wernig, M., Markoulaki, S., Sun, C.-W., Meissner, A., Cassady, J. P., Beard, C., Brambrink, T., Wu, L.-C., and Townes, T. M. (2007). Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318, 1920-1923.

Jarvis, E. D., Mirarab, S., Aberer, A. J., Li, B., Houde, P., Li, C., Ho, S. Y., Faircloth, B. C., Nabholz, B., and Howard, J. T. (2014). Whole-genome analyses resolve early branches in the tree of life of modern birds. Science 346, 1320-1331.

Jiang, Q., Zhao, Y., Zhang, X., Yang, X., Chen, Y., Chu, Z., Ye, Q., Li, X., Yin, Z., and You, J. (2019). Surface passivation of perovskite film for efficient solar cells. Nature Photonics 13, 460-466.

Kimbrel, E. A., and Lanza, R. (2015). Current status of pluripotent stem cells: moving the first therapies to the clinic. Nature reviews Drug discovery 14, 681-692.

Li, L., Yu, Y., Ye, G. J., Ge, Q., Ou, X., Wu, H., Feng, D., Chen, X. H., and Zhang, Y. (2014). Black phosphorus field-effect transistors. Nature nanotechnology 9, 372-377.

Masui, S., Nakatake, Y., Toyooka, Y., Shimosato, D., Yagi, R., Takahashi, K., Okochi, H., Okuda, A., Matoba, R., and Sharov, A. A. (2007). Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nature cell biology 9, 625-635.

Mercer, J. (2018). "Reputation and international politics," Cornell University Press.

Murphy, S. L., Xu, J., Kochanek, K. D., and Arias, E. (2018). Mortality in the united states, 2017.

Naidoo, J., Wang, X., Woo, K. M., Iyriboz, T., Halpenny, D., Cunningham, J., Chaft, J. E., Segal, N. H., Callahan, M. K., and Lesokhin, A. M. (2017). Pneumonitis in patients treated with anti–programmed death-1/programmed death ligand 1 therapy. Journal of Clinical Oncology 35, 709.

Niwa, H., Ogawa, K., Shimosato, D., and Adachi, K. (2009). A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature 460, 118-122.

Okita, K., Matsumura, Y., Sato, Y., Okada, A., Morizane, A., Okamoto, S., Hong, H., Nakagawa, M., Tanabe, K., and Tezuka, K.-i. (2011). A more efficient method to generate integration-free human iPS cells. Nature methods 8, 409-412.

Samanta, S., Rajasingh, S., Drosos, N., Zhou, Z., Dawn, B., and Rajasingh, J. (2018). Exosomes: new molecular targets of diseases. Acta Pharmacologica Sinica 39, 501-513.

Scudellari, M. (2016). A decade of iPS cells. Nature 534, 310-313.

Sharma, K., Kaith, B., Kumar, V., Kalia, S., Kumar, V., and Swart, H. (2014). Water retention and dye adsorption behavior of Gg-cl-poly (acrylic acid-aniline) based conductive hydrogels. Geoderma 232, 45-55.

Sidney, S., Quesenberry, C. P., Jaffe, M. G., Sorel, M., Nguyen-Huynh, M. N., Kushi, L. H., Go, A. S., and Rana, J. S. (2016). Recent trends in cardiovascular mortality in the United States and public health goals. JAMA cardiology 1, 594-599.

Sinha, A., Shen, Z., Song, Y., Ma, H., Eide, D., Hsu, B.-J., and Wang, K. (2015). An overview of microsoft academic service (mas) and applications. In "Proceedings of the 24th international conference on world wide web", pp. 243-246.

Spence, A., Poortinga, W., Butler, C., and Pidgeon, N. F. (2011). Perceptions of climate change and willingness to save energy related to flood experience. Nature climate change 1, 46-49.

Sun, Y.-C. (2009). Voice blog: An exploratory study of language learning. Language Learning & Technology 13, 88-103.

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. cell 131, 861-872.

Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. cell 126, 663-676.

Thangavel, J., Samanta, S., Rajasingh, S., Barani, B., Xuan, Y.-T., Dawn, B., and Rajasingh, J. (2015). Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. Journal of cell science 128, 3094-3105.

Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., and Jones, J. M. (1998). Embryonic stem cell lines derived from human blastocysts. science 282, 1145-1147.

Tongers, J., Losordo, D. W., and Landmesser, U. (2011). Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges. European heart journal 32, 1197-1206.

Tulloch, N. L., Muskheli, V., Razumova, M. V., Korte, F. S., Regnier, M., Hauch, K. D., Pabon, L., Reinecke, H., and Murry, C. E. (2011). Growth of engineered human myocardium with mechanical loading and vascular coculture. Circulation research 109, 47-59.

Vanham, D., Leip, A., Galli, A., Kastner, T., Bruckner, M., Uwizeye, A., Van Dijk, K., Ercin, E., Dalin, C., and Brandão, M. (2019). Environmental footprint family to address local to planetary sustainability and deliver on the SDGs. Science of the Total Environment 693, 133642.

Wilmut, I., Schnieke, A. E., McWhir, J., Kind, A. J., and Campbell, K. H. (1997). Viable offspring derived from fetal and adult mammalian cells. nature 385, 810-813.

Zhang, F., Pant, D., and Logan, B. E. (2011). Long-term performance of activated carbon air cathodes with different diffusion layer porosities in microbial fuel cells. Biosensors and Bioelectronics 30, 49-55.




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